EVIDENCE OF FOCUSING THE MHC CLASS I IMMUNOPEPTIDOME BY TAPASIN

Evidence of focusing the MHC class I immunopeptidome by tapasin

Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer.MHC-I is highly polymorphic and each allotype is promiscuous, and capable of binding a unique and diverse repertoire of peptide ligands.The peptide editing chaperone tapasin optimizes this allotype speci

read more



In Vitro Antifungal Drug Resistance Profiles of Clinically Relevant Members of the Mucorales (Mucoromycota) Especially with the Newer Triazoles

Mucoromycoses (infections caused by members rubbermaid 8 gallon trash can of the order Mucorales, phylum Mucoromycota [ex-Zygomycota]) are highly destructive, rapidly progressive infections, with dire prognoses especially when they occur in immunocompromised hosts.Current treatment guidelines recommend liposomal formulations of amphotericin B with

read more